2-Minute Neuroscience: THC

THC is the main psychoactive component of cannabis. In this video, I discuss the effects of THC on the nervous system.

TRANSCRIPT:

THC is the main psychoactive component of cannabis, and one of a class of compounds known as cannabinoids. Cannabis tends to be relatively low in THC compared to its levels of a THC precursor, THCA. Heating the cannabis plant, however, causes the conversion of THCA to THC, which is part of the basis for heating or burning the plant for use. The effects of cannabis may vary depending on the variety of cannabis plant and its associated levels of THC and other cannabinoids, but common effects of THC include: euphoria, sedation, stimulation of appetite, impaired cognitive function, analgesia, and anxiety.

THC is thought to exert most of its effects by binding to receptors called cannabinoid receptors. There are two known cannabinoid receptors, CB1 and CB2--both of which are g-protein coupled receptors. CB1 receptors are found throughout the nervous system, while CB2 receptors are primarily found on immune cells. THC acts as a partial agonist at cannabinoid receptors, meaning it binds to these receptors and generates a response that’s a fraction of what other substances that bind to the receptors can generate. THC interacts with a number of other targets as well, but it’s thought that its main psychoactive effects are mediated through its action at CB1 receptors.

Activation of CB1 receptors is thought to lead to the modulation of the release of various neurotransmitters. It’s not fully understood how this translates into the characteristic effects of THC, but the activation of CB1 receptors in different areas of the nervous system may partially explain the effects of the drug. CB1 receptors in areas like the cortex and hippocampus, for example, may be involved in the perceptual and cognitive effects of THC, CB1 receptors in areas like the basal ganglia and cerebellum may be associated with sedation and effects on movement, and CB1 receptors in areas like the spinal cord and brainstem may be linked to analgesic effects.

REFERENCES:

Banister SD, Arnold JC, Connor M, Glass M, McGregor IS. Dark Classics in Chemical Neuroscience: Δ9-Tetrahydrocannabinol. ACS Chem Neurosci. 2019;10(5):2160‐2175. doi:10.1021/acschemneuro.8b00651

Howlett AC, Barth F, Bonner TI, et al. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev. 2002;54(2):161‐202. doi:10.1124/pr.54.2.161

Pertwee RG. Pharmacological actions of cannabinoids. Handb Exp Pharmacol. 2005;(168):1‐51. doi:10.1007/3-540-26573-2_1

Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol. 2008;153(2):199‐215. doi:10.1038/sj.bjp.0707442
@sandiago7564 : Fun Fact, Early drafts of the American Declaration of Independence were drafted on Hemp paper.
@SouthAfricanCannabisExtraction : Really great job to get such solid content into 2mins! Wow
@KoolT : Thank you so much I was severely injured 30 years ago and use this for pain control now that my pain is at level 2 or less. So thankful not to be on opioid painkillers anymore. Stay FIT.
@KeyserTheRedBeard : astounding upload Neuroscientifically Challenged. I shattered the thumbs up on your video. Continue to keep up the wonderful work.
@ryanfrizzell736 : Great video. Now I'm more informed about the neuroscience of THC use. Thank you

브라운티거 X 조광일(Brown Tigger X Gwangil Jo) - THC(Two Harsh Carls) [82 SOUND]

지난달 1일 싱글앨범 [곡예사] 로 많은 주목을 받은 신인 조광일과 "2020 월간 브라운 프로젝트" 의 브라운티거가 두번째 합작을 발표했다.
이들은 작년 가을 여러 밈을 만들고 하반기를 휩쓸었던 "딱딱해" 의 원작 비트를 활용해 [Grow back] 이라는 새로운 곡을 탄생시켜 좋은 평을 받았었다.
이번 콜라보레이션 싱글앨범 [THC] 는 디핀칼즈 레코즈 (Dippin' carls records) 의 방향성을 보여주고 있다.

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@user-jj2fe2rb1g : 진짜 위로 올라왔음 하는 아티스트 1순위다
@user-bu5um6ho6e : 100% 떡상하는 안전자산들이니까
힙잘알들은 안심하고 베팅하시면 됩니다
@hentai_kittyy : 버드와이저 마시는 조광일.. 메모....
@user-dx4ev2es1p : 티거랑 광일이형 진짜 개간지난다
@user-bd3ej2ev1w : 난 이게 조광일 노래중 젤 좋은데 이상하리만큼 조회수가 적네;

How Weed Works: THC

Hank explains the science behind the effects of that wackiest of weeds, cannabis sativa - aka marijuana.

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Citations
http://www.nida.nih.gov/infofacts/marijuana.html
http://science.howstuffworks.com/marijuana3.htm
http://www.chm.bris.ac.uk/motm/anandamide/ananh.htm
http://medicalmarijuana.procon.org/view.answers.php?questionID=637
The Botany of Desire by Michael Pollan
http://www.springerlink.com/content/q450642638287947/
http://www.nytimes.com/2008/09/09/science/09obdrug.html

Images
http://upload.wikimedia.org/wikipedia/commons/d/d1/THC.svg
http://upload.wikimedia.org/wikipedia/commons/b/b7/Cannabis_plant2.jpg
http://upload.wikimedia.org/wikipedia/commons/f/f9/Rnt_Anandamide.jpg
http://upload.wikimedia.org/wikipedia/commons/4/44/Cannabinoid_Receptor.png
@lemissa1 : I'm really sad they didn't shorten the video by 4 seconds.
@PoshDesignsHD : Came here high af to learn. Interesting shit. Im just sitting here blazed af, and learning what its doing to me.. I love stoner shit
@davidj2826 : Hank's a stoner. "Delicious brick of marijuana"
@XAVIERCUERVO : its always good to learn new things
too bad i will forget this by the time i finish writing this comment .... time to activate my cannabinoid receptors one more time
@Xakslied : I'm 100% sure That Hank was high when they recorded this

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