@kosmikj5926 : Such a 180 degree turn from your first video about thca. Glad to see that you delved more into it and made the decision to offer this medicine to your patrons and to do it responsibly. On a side note, i did have an issue with a defective item from my order that i thought was handled by customer service in not a great way. The issue was not resolved and i just let it go as the item was less than $20.
@RQFumbles : Was told by a shop in Texas that THCa smoked is almost the same if not the exact same as smoking THC. They are a "product of the product" so best believe they know what they are talking about. Tried some and I'm sold. Definitely give it a try!
@mrpipestache2423 : And the best part is they don't have to spray the flower with distillate on it. It's like normal flower. It would be a good idea to put in some law enforcement notes for peoples orders. I'm excited to try your flower once it's up! Will I be able to ship to South Dakota?
@SMOKER420 : I subscribed yesterday and I think this is a Great THC-A educational video!
@spiritscollective : Just left your shop 15min ago and got some THC a flower. Excited to try it.

THC and THCa Cannabinoids

THC and THCa Cannabinoids

Professor DeBacco


Research Article
Russo, E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects. British journal of pharmacology, 163(7), 1344-1364.
https://www.researchgate.net/publication/51485891_Taming_THC_Potential_cannabis_synergy_and_phytocannabinoid-terpenoid_entourage_effects

The Famous One…
THCA or tetrahydrocannabinolic acid is one of the most recognized cannabinoid ever to be discovered.
While there are multiple compounds in cannabis that offer medicinal effects, and many more that modulate the impact of THC, there are none with such a psychoactive impact as THC.

THC Effect
The effect of consuming decarboxylated THCA, or THC, in high doses can cause near hallucinations for some.
Although the effect is not technically “intoxicating,” it is certainly inebriating and often very psychedelic.

The Molecule That Started the War
It is this cannabinoid that is the target of the now fading drug war, which characterized cannabis as a dangerous and addictive drug.
In the absence of THCA, there may never have been a war against cannabis.

Original Source is CBGA
THCA, like CBDA, is synthesized from CBGA in the apoplastic space of the secretory vesicle in the trichome.
The enzyme that does the work is THCAS or THCA synthase.
Again, there is a peroxide byproduct which is toxic to the cell, and therefore THCAS biosynthesis must occur in the trichome secretory vessel.

THC and Regulations
Current regulations require that all CBD hemp flowers with a THC content greater than 0.3% are thereby classified as “marijuana,” and must be destroyed.

There are a few exceptions to the rule of THCAS producing THCA, and CBDAS producing CBDA.


Biological Expectations vs Regulations
Research from Oregon CBD company has shown that in vitro, CBDAS will produce one part THCA for every 20 parts CBDA.

Therefore, with cannabinoid contents of hemp exceeding 20%, it may be totally unreasonable to have the THCA content requirement set to 0.3% or less, because we can biologically expect a minimum of 1% THCA for every 20% of CBDA produced by CBDAS, the required synthase for CBDA production.

THC Interactions
THC primarily interacts with the CB1 receptor in the endocannabinoid system.
For the majority, these receptors are found on the nervous system tissues.
When bound by THC, they modulate the electrochemical systems that allow us to perceive the world, presumably resulting in the psychoactive effect.

THC vs Aspirin
This may also explain its analgesic, muscle relaxant, and antispasmodic properties (Pacher et al., 2006).
THC has been shown to have “20 times the anti-inflammatory power of aspirin and twice that of hydrocortisone” (Evans 1991, Russo 2011).







Link to Lecture Slides: https://drive.google.com/file/d/1lon5qsVTq6Hwgvrtx37riCX6fRc4Yfqv/view?usp=sharing

*Due to the description character limit the full work cited for "THC and THCa Cannabinoids" can be viewed at... https://drive.google.com/file/d/1sHnZpOj_WtjS1bkmNuMQpxnXca9DzCL3/view?usp=sharing
@christopherfreeman1340 : THC and spices such as turmeric,ginger,cinnamon and amala (sour gooseberry) is the way to treat acute and chronic diseases.
@pataniki8034 : who would have guessed way back when that there was so much more than just a plant / weed you could smoke instead of tobacco...and for health reasons...not just fun
@vincentkoenst913 : Here in The Netherlands it must be 1% or less instead of 0.3% to be completely legal
@scottturner2529 : Love the trichome diagram.
@leonardohamadi6745 : Awesome content. But I think, as my political opinion, that prohibition came from big lobbies, big companies..




@DopeasYola : THIS IS A GAME CHANGER!!!!
IG : https://www.instagram.com/dope.as.yola/
TIK TOK : https://www.tiktok.com/@dope.as.yola?lang=en
TWITTER : https://twitter.com/dope_as_yola_?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor
@crispycream21vase50 : From taking videos on a phone to having a full time podcast and 6 business love to see the growth
@LavaBoyVolcanoPlays : Man I’m so happy for not only us fans, but for your younger self. Imagine getting to tell 15 year old you u are making LEGAL BUD!!! You have something to be really proud of here Yola, love ya man
@nathanvekovius465 : So glad you explained it correctly and didn’t overhype it like it’s some new cannabinoid. You explained it right off the rip and educated your fan base which is wayyy more than a lot of other creators can say. Hella respect for that Yola great video and I’m sure many people who didn’t fully explain it now understand
@finalargument8644 : Man this is a huge achievement, I’m so proud as to what you and the community have created. It’s inspiring. Keep pushin Thomas!

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